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Disappearance of Vascular Calcifications During Treatment of Renal Osteodystrophy: Two Patients Treated with High Doses of Vitamin D and Aluminum Hydroxide

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▸Requests for reprints should be addressed to Dr. R. Verberckmoes, A.Z. St. Rafaël, Afeling Nefrologie, Kapucijnenvoer 33, 3000, Leuven, Belgium.

Leuven, Belgium, and Heidelberg,Germany

Ann Intern Med. 1975;82(4):529-533. doi:10.7326/0003-4819-82-4-529
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In two patients with chronic renal failure, extensive renal osteodystrophy, and vascular calcifications, treatment with high doses of vitamin D3 and aluminum hydroxide was followed by healing of the osteodystrophy and marked resolution of the vascular calcifications. The importance of adequate serum phosphate control during this treatment is stressed. It is postulated that the presence of pathologic bone that was rendered more avid for mineral by the action of vitamin D contributed to the disposal of calcium and phosphorus derived from the calcified vessels and from a positive external balance.





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