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D-Penicillamine Induced Goodpasture's Syndrome in Wilson's Disease

IRMIN STERNLIEB, M.D.; BOYCE BENNETT, M.D.; and I. HERBERT SCHEINBERG, M.D.
[+] Article and Author Information

Grant support: grant AM 1059, National Institute of Arthritis, Metabolism and Digestive Diseases.

▸Requests for reprints should be addressed to Irmin Sternlieb, M.D., Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.


Ann Intern Med. 1975;82(5):673-676. doi:10.7326/0003-4819-82-5-673
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Fatal pulmonary hemorrhages and rapidly progressive glomerulonephritis occurred in three patients with Wilson's disease (hepatolenticular degeneration) who had been treated with penicillamine for 2 to 3½ years. Light microscopic studies of the kidneys showed severe glomerulonephritis with crescent formation, and the lungs showed intraalveolar hemorrhages. Although the clinical and pathologic abnormalities were those of Goodpasture's syndrome, immunofluorescence microscopic studies in the one case tested showed an interrupted, rather than linear, fluorescence pattern.

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