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Diagnosis and Treatment |

Drug Spotlight Program: Alcohol and Its Drug Interactions

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▸Requests for reprints should be addressed to Frank A. Seixas, M.D., Medical Director, National Council on Alcoholism, Room 1720, 2 Park Avenue, New York, NY 10016.

Ann Intern Med. 1975;83(1):86-92. doi:10.7326/0003-4819-83-1-86
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Alcohol interacts with a surprising number of commonly used drugs: antibiotics, anticoagulants, antihistamines, digitalis, monoamine oxidase inhibitors, nitroglycerine, diuretics, heavy metals, insulin, iron, puromycin C, and many others. It also interacts specifically with sedatives, opiates, phenothiazines, antidepressants, and other psychoactive drugs. This review calls attention to these interactions and what we know of their mechanisms. The physician is cautioned about the use of alcohol by his patients taking other medications and about the frequent difficulty of ascertaining the extent of the patient's alcohol ingestion.





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