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Dilantin®-Induced Disseminated Intravascular Coagulation with Purpura Fulminans: A Case Report

STEPHAN R. TARGAN, M.D.; MARK R. G. CHASSIN, M.D.; and LUCIEN B. GUZE, M.D., F.A.C.P.
[+] Article and Author Information

▸Requests for reprints should be addressed to Lucien B. Guze, M.D., (691/151), Chief of Staff for Research and Education, Veterans Administration (Wadsworth) Hospital Center, Wilshire and Sawtelle Boulevards, Los Angeles, CA 90073.


Torrance, California, and Los Angeles, California


Ann Intern Med. 1975;83(2):227-230. doi:10.7326/0003-4819-83-2-227
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A patient developed disseminated intravascular coagulation with purpura fulminans 1 month after starting Dilantin® therapy for a seizure disorder. In addition, the patient developed exfoliative dermatitis, hepatitis, cutaneous vasculitis, and microangiopathic hemolytic anemia. She was successfully treated with adrenal steroids and heparin for her purpura fulminans. The hepatitic dermatologic, along with hemorrhagic, complications of Dilantin® are reviewed, and the possible origin of the vasculitis and disseminated intravascular coagulation is discussed.

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