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Bone-Marrow Aspiration and Biopsy

ARKADI M. RYWLIN, M.D.
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Department of Pathology and Laboratory Medicine
Mount Sinai Medical Center of Greater Miami
Miami Beach, Florida 33140


Ann Intern Med. 1975;83(2):282-283. doi:10.7326/0003-4819-83-2-282_2
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To the editor: In a recent paper, "Bilateral Trephine Bone-Marrow Biopsies in Lymphoma and Other Neoplastic Diseases," (1) the authors state that "the superiority of bone-marrow biopsy over bone-marrow aspiration in defining extent of disease has been well established in Hodgkin's and non-Hodgkin's malignant lymphoma and carcinoma metastatic to bone marrow." A review of the quoted references shows that histologic sections were found to be superior to smears in evaluating the presence of malignant lymphoma or metastatic carcinoma in bone marrow. Histologic sections of bone marrow can be obtained by aspiration as well as biopsy. To the best of my

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