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Focal Nodular Hyperplasia of the Liver and Intrahepatic Hemorrhage in Young Women on Oral Contraceptives

J. Q. STAUFFER, M.D.; M. W. LAPINSKI, M.D.; D. J. HONOLD, M.D.; and J. K. MYERS, M.D.
[+] Article and Author Information

Grant support: in part by grant RR-229, General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health.

▸Requests for reprints should be addressed to John Q. Stauffer, M.D., Gastroenterology Section, Department of Medicine, State University Hospital, 750 E. Adams St., Syracuse, NY 13210.


Syracuse, New York


Ann Intern Med. 1975;83(3):301-306. doi:10.7326/0003-4819-83-3-301
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Focal nodular hyperplasia of the liver may occur with increased frequency in young women who have been taking oral contraceptives. Patients may present with massive intraperitoneal hemorrhage requiring immediate surgical intervention. These nodules may be multiple and occasionally pedunculated, mimicking ovarian cysts. Liver function tests are nondiagnostic. A liver scan and arteriogram are often helpful in determining a diagnosis. Percutaneous liver biopsy is contraindicated. Large nodules should be resected, and continued use of oral contraceptives is contraindicated.

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