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Bullous Dermatosis of Hemodialysis

[+] Article and Author Information

Grant support: in part by U.S. Public Health Service Grant AM05605-07.

▸Requests for reprints should be addressed to Barbara Gilchrest, M.D., Photobiology Unit, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114.

Boston, Massachusetts

Ann Intern Med. 1975;83(4):480-483. doi:10.7326/0003-4819-83-4-480
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Five patients with chronic renal failure who were undergoing maintenance hemodialysis developed a self-limited bullous dermatosis restricted to light exposed areas, primarily involving the dorsa of the hands. Porphyrin levels and phototesting were normal, but histologic sections of the bullae showed thickening of venule walls, hypogranulated mast cells, and perivenular deposition of immunoglobulins. This combination of features has not previously been described and may reflect a pathologic process unique to chronic hemodialysis.





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