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Demeclocycline Treatment in the Syndrome of Inappropriate Antidiuretic Hormone Secretion

DAVID A. CHERRILL, M.D.; ROBERT M. STOTE, M.D.; JAMES R. BIRGE, M.D.; and IRWIN SINGER, M.D., F.A.C.P.
[+] Article and Author Information

Doctors Stote and Cherrill are supported by Smith Kline & French Laboratories. Doctor Singer is supported, in part, by Lederle Laboratories.

▸Requests for reprints should be addressed to Robert M. Stote, M.D., 51 North 39th St., Philadelphia, PA 19104.


Philadelphia, Pennsylvania


Ann Intern Med. 1975;83(5):654-656. doi:10.7326/0003-4819-83-5-654
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We have studied the effects of demeclocycline on the water metabolism of a patient with the syndrome of inappropriate antidiuretic hormone (ADH) secretion who presented with a serum sodium concentration of 110 meq/litre. Free water clearance was studied before, during, and after treatment with demeclocycline. This study shows that demeclocycline (900 mg/day) can at least partially inhibit the action of ADH in the setting of tumor-induced ADH secretion, with the production of a reversible, partial nephrogenic diabetes insipidus, and with few or no side effects. Demeclocycline may be useful in the treatment of chronic inappropriate ADH secretion.

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