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Sideroblastic Anemia with Splenic Abscess and Fatal Thromboemboli after Splenectomy

SYED H. ALEALI, M.D.; OSWALDO CASTRO, M.D.; RICHARD P. SPENCER, M.D., Ph.D.; and STUART C. FINCH, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Richard P. Spencer, M.D., Ph.D., Department of Nuclear Medicine, University of Connecticut Health Center, Farmington, CT 06032.


New Haven, Connecticut, and Farmington, Connecticut


Ann Intern Med. 1975;83(5):661-663. doi:10.7326/0003-4819-83-5-661
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A man with sideroblastic anemia had a splenectomy because of a salmonella abscess of the spleen that had ruptured into the colon. Two months later he developed recurrent thrombophlebitis and fatal thromboembolism associated with thrombocytosis. A review of the literature showed multiple additional cases of sideroblastic anemia with thrombocytosis and thromboembolism after splenectomy. In many of these cases the patient died. Splenectomy for treatment of a sideroblastic anemia probably is contraindicated. If splenectomy is done, long-term therapy to avoid thromboembolic complications probably should be maintained for many months or even years.

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