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The Virus Hypothesis in Systemic Lupus Erythematosus

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Grant support: in part by a grant from the John Lindsley Fund, and grants from the U.S. Public Health Service, AM 14627 and AM 17028.

▸Requests for reprints should be addressed to Paul E. Phillips, M.D., Hospital for Special Surgery, 535 East 70th St., New York, NY 10021.

New York, New York

Ann Intern Med. 1975;83(5):709-715. doi:10.7326/0003-4819-83-5-709
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Type-C viruses are currently the prime etiologic candidates in systemic lupus erythematosus. On the basis of knowledge gained from studies of experimental and human models of chronic viral disease, there are possible pathogenetic roles of a virus in systemic lupus erythematosus. Experimental attempts at implicating specific viruses have been predominantly negative, but evidence for enhanced type-C-virus expression has recently been reported.





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