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Immunosuppressive Therapy in Lupus Erythematosus

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Division of Rheumatic Diseases, Department of Medicine, School of Medicine, University of Connecticut, Farmington, Connecticut

Ann Intern Med. 1975;83(5):727-728. doi:10.7326/0003-4819-83-5-727
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The use of immunosuppressive therapy in patients with systemic lupus erythematosus has become widespread during the past few years because of a number of reports describing its efficacy. These reports suggest that the use of cytotoxic drugs with corticosteroids leads to a more favorable outcome than treatment with corticosteroids alone. The enthusiastic use of several of these agents is now common and is not always reserved for those patients with life-threatening disease. Most of the literature upon which such enthusiasm is based consists of case reports or uncontrolled trials. Other studies have compared a group of patients recently treated with


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