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Reduction of Infarct Size by Oxygen Inhalation

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Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York

Ann Intern Med. 1975;83(6):897-898. doi:10.7326/0003-4819-83-6-897
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Oxygen is usually administered to patients with acute myocardial infarction with the rationale that it might reduce the extent and severity of myocardial ischemia and diminish or eliminate ventricular irritability. This therapy, which is based on a priori reasoning, has been used by successive generations of physicians with remarkably few, if any, experimental studies to document its value. In patients with coronary artery disease and with arterial oxygen desaturation due to pulmonary congestion, intrinsic lung disease, or altered closing lung volumes with pulmonary arteriovenous shunting, the benefits of increasing the fraction of inspired oxygen (FIO2) above 20% to obtain normal


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