0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Original Research |

Familial Hyperparathyroidism: Description of a Large Kindred with Physiologic Observations and a Review of the Literature

RICHARD E. GOLDSMITH, M.D., F.A.C.P.; GLEN W. SIZEMORE, M.D.; I-WEN CHEN, Ph.D.; ELIZABETH ZALME, B.S.; and WILLIAM A. ALTEMEIER, M.D.
[+] Article and Author Information

Grant support: in part by the Young Fund; U.S. Public Health Service grant no. 5-T01 AM05165; National Institutes of Health grant no. RR-00068; and the Mayo Foundation.

▸Requests for reprints should be addressed to Richard E. Goldsmith, M.D., University of Cincinnati College of Medicine, Room 5564, 231 Bethesda Ave., Cincinnati, OH 45267.


Cincinnati, Ohio, and Rochester, Minnesota


Ann Intern Med. 1976;84(1):36-43. doi:10.7326/0003-4819-84-1-36
Text Size: A A A

Sixty-nine out of a kindred of 100 members covering five generations were examined and studied, and 34 were hypercalcemic. Sixteen subjects were believed, on the basis of laboratory and clinical observations, to have primary hyperparathyroidism. Eight patients were subjected to exhaustive study to identify polyendocrine involvement before neck exploration. No coexisting endocrine abnormalities were found; operation showed multiparathyroid gland involvement in most instances. Measurement of immunoassayable calcitonin and assessment of renal and gut function were carried out in 37 subjects to search out possible causes of "reactive" parathyroid gland hyperfunction. While no such cause-effect relationship was noted for this kindred, 16 of the subjects so tested had serum calcitonin content below the assay limits of sensitivity. What role this apparent lack of calcitonin played in the development of hyperparathyroidism (or vice versa) needs clarification.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)