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H2-Receptor Antagonists in the Treatment of Peptic Ulcer

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Chief, Gastroenterology Section, Veterans Administration Wadsworth Hospital Center, Los Angeles, California

Ann Intern Med. 1976;84(2):212-214. doi:10.7326/0003-4819-84-2-212
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Although there has been a definite decrease in the incidence of peptic ulcer during the past 10 to 20 years, particularly in duodenal ulcer, it still remains one of the major causes of absenteeism and morbidity in the United States (1). Antacids and anticholinergics remain the mainstay of ulcer therapy despite lack of clear cut evidence that they relieve ulcer pain, expedite ulcer healing, or decrease recurrences and complications. Because antacids buffer gastric acid and anticholinergics inhibit the secretion of acid and pepsinogen, their use in the therapy of peptic ulcer is rational. Their therapeutic effect, however, is not striking


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