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Serum Lipid Levels in Angiographically Defined Coronary Artery Disease

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Grant support: U.S. Public Health Service grants HL-11306 and HL-13167.

▸Requests for reprints should be addressed to Peter F. Cohn, M.D., Department of Medicine, Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston, MA 02115.

Boston, Massachusetts

Ann Intern Med. 1976;84(3):241-245. doi:10.7326/0003-4819-84-3-241
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To evaluate the association between serum cholesterol and triglyceride levels and angiographically determined coronary artery disease, two selected groups of 100 patients each were compared. The coronary artery disease group had significantly higher serum levels of both cholesterol and triglyceride. However, several types of analyses based on the quartile distribution of serum levels of cholesterol and triglyceride showed that the serum cholesterol level was more significantly associated with coronary artery disease than was the triglyceride level. This was especially true in relation to multivessel disease, the most severe form of coronary artery disease, and most marked in men. Association with coronary artery disease appeared to be continuous, rather than being related to any critical serum level, thus re-emphasizing the need to distinguish between desirable and average levels of serum cholesterol in countries with a high dietary intake of saturated fat.





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