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1-Alphahydroxycholecalciferol in Chronic Renal Failure: Studies of the Effect of Oral Doses

M. W. J. DAVIE, M.B.; T. M. CHALMERS, M.D.; J. O. HUNTER, M.D.; B. PELC, Ph.D.; and E. KODICEK, M.D., Ph.D., F.R.S.
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▸Requests for reprints should be addressed to T. M. Chalmers, M.D., Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, England.


Ann Intern Med. 1976;84(3):281-285. doi:10.7326/0003-4819-84-3-281
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Four patients with advanced chronic renal failure and osteodystrophy were treated with 1-alphahydroxycholecalciferol, a synthetic vitamin D analogue, in a daily oral dose of 1.5 to 2.0 µg, for periods up to 1 year. They showed increased calcium absorption, positive calcium and phosphorus balances, moderate increases in serum calcium levels, marked reductions in serum alkaline phosphatase levels, a decrease in serum immunoreactive parathyroid hormone levels, and radiologic and histologic improvement in bone disease. One patient with proximal myopathy showed improvement in muscular strength. 1-Alphahydroxycholecalciferol appears to be effective therapy for renal osteodystrophy.





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