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The Effect of Various Forms of Milk on Gastric-Acid Secretion: Studies in Patients with Duodenal Ulcer and Normal Subjects

ANDREW F. IPPOLITI, M.D.; VERNON MAXWELL, B.S.; and JON I. ISENBERG, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: grant AM 17328 from the National Institute of Arthritis, Metabolism, and Digestive Diseases to CURE (Center for Ulcer Research and Education); and the Veterans Administration Research Funds, project number 4340-13.

▸Reprint requests should be addressed to Jon Isenberg, M.D., Wadsworth Veterans Administration Hospital, Los Angeles, CA 90073.


Los Angeles, California


Ann Intern Med. 1976;84(3):286-289. doi:10.7326/0003-4819-84-3-286
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Milk is commonly recommended as therapy for patients with peptic ulcer. The purpose of this study was to examine the effect of various forms of milk and 0.15 M NaCl (control) on gastric-acid secretion in five patients with duodenal ulcer during a period of remission and in five normal subjects. A significant (P < 0.05) increase in acid secretion in both groups was produced by 240 ml of whole, low-fat, and nonfat milk. The acid secretory responses to milk were equivalent to those produced by a 300-ml 10%-peptone meal and were approximately 20% to 35% of maximal betazole- or pentagastrin-stimulated acid output. Gastric-acid secretion did not increase after 0.15 M NaCl. Low-calcium milk produced a significant (P < 0.05) increase in acid secretion in the patients with duodenal ulcer but not in the normal subjects. Because milk contains both protein and calcium, and each are stimulants of gastric-acid secretion, there is reason to question its frequent ingestion by patients with peptic ulcer.

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