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Combination Chemotherapy for Advanced Breast Cancer: Response and Effect on Survival

GEORGE P. CANELLOS, M.D., F.A.C.P.; VINCENT T. DeVITA, M.D., F.A.C.P.; G. LENNARD GOLD, M.D., F.A.C.P.; BRUCE A. CHABNER, M.D., F.A.C.P.; PHILIP S. SCHEIN, M.D., F.A.C.P.; and ROBERT C. YOUNG, M.D., F.A.C.P.
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▸Requests for reprints should be addressed to Robert C. Young, M.D., National Cancer Institute, Bldg. 10, Room 12N236, Bethesda, MD 20014.


Bethesda, Maryland


Ann Intern Med. 1976;84(4):389-392. doi:10.7326/0003-4819-84-4-389
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Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF (P), which included methotrexate, 60 mg/m2, and 5-fluorouracil, 700 mg/m2, intravenously on the first and eighth days, in addition to cyclophosphamide, 100 mg/m2, and prednisone, 40 mg/m2, by mouth daily from the first to the fourteenth day of a 28-day cycle. Only 2 of 25 patients responded to hormonal therapy or endocrine ablation. Twenty-seven of the 40 patients (68%) had a complete response (8 patients) or partial response (19 patients). Lung, soft tissue, and nodal metastases were the most responsive sites. The median duration of antitumor response was 8 months, with a median survival of 18 months for the responding group. The nonresponders had a median survival of 4 months. The toxicity was primarily hematologic and was especially severe in patients with functional liver impairment due to metastatic disease.

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