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Intravascular Coagulation with Use of Human Prothrombin Complex Concentrates

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Grant support: in part by Grants HL 06350 and HL 14228 SCOR, Thrombosis Center, National Heart and Lung Institute; and Grant AM 05345, National Institute of Arthritis, Metabolic and Digestive Diseases, National Institutes of Health.

▸Requests for reprints should be addressed to Philip M. Blatt, M.D.; Department of Medicine, University of North Carolina; Chapel Hill, NC 27514.

Chapel Hill, North Carolina

Ann Intern Med. 1976;84(6):683-687. doi:10.7326/0003-4819-84-6-683
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Prothrombin complex concentrates are used in the treatment of the congenital bleeding disorders associated with Factors II, VII, IX, and X deficiencies. They have also been extensively used to treat acquired coagulation abnormalities secondary to vitamin K deficiency, warfarin ingestion, and various types of liver disease. The reported complications of prothrombin complex concentrates administration include hepatitis, anaphylaxis, and thrombosis. This paper documents the development of disseminated intravascular coagulation in association with the administration of prothrombin complex concentrates to patients with liver disease.





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