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Inhibition of Stimulated Gastric Secretion by an Orally Administered Prostaglandin Capsule: A Study in Normal Men

DONALD E. WILSON, M.D., F.A.C.P.; JOHN QUERTERMUS, M.D.; MANFRED RAISER, M.D.; JAMES CURRAN; and ANDRÉ ROBÉRT, M.D., Ph.D.
[+] Article and Author Information

Presented in part 6 November 1975, at the Annual Meeting of the American Federation for Clinical Research, Midwest Section; Chicago, Illinois.

▸Requests for reprints should be addressed to Donald E. Wilson, M.D., F.A.C.P.; 840 South Wood Street; Chicago, IL 60612.


Chicago, Illinois


Ann Intern Med. 1976;84(6):688-691. doi:10.7326/0003-4819-84-6-688
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The effect of ingestion of a gelatin capsule containing 127 µg of 16,16-dimethyl prostaglandin E2 (DM-prostaglandin E2) or a liquid containing 127 µg of DM-prostaglandin E2 on stimulated gastric secretion in man was studied. DM-prostaglandin E2 significantly reduced the volume, acid concentration, and total acid output of gastric secretion. Secretory inhibition during the 3 h after treatment with the capsule was 37% (volume), 39% (acid concentration), and 60% (acid output). The DM-prostaglandin E2 capsule was nearly as effective as an equivalent amount of DM-prostaglandin E2 in solution. Prostaglandin analogues, because of their oral effectiveness and duration of action, may have therapeutic value in peptic ulcer disease.

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