0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Paroxysmal Nocturnal Hemoglobinuria and Marrow Failure Treated by Infusion of Marrow from an Identical Twin

A. FEFER, M.D.; H. FREEMAN, M.D.; R. STORB, M.D.; J. HILL, M.D.; J. SINGER, M.D.; A. EDWARDS, M.D., F.A.C.P.; and E. THOMAS, M.D.
[+] Article and Author Information

Grant support: Grants CA 10895, CA 05231, CA 15704 from the National Cancer Institute and RR-37 from the General Clinical Research Center, National Institutes of Health. Dr. Fefer is a Scholar of the Leukemia Society of America and a Sinsheimer Fellow. Dr. Freeman was supported during a portion of this work as a Medical Research Council of Canada Fellow. Dr. Thomas is a recipient of Research Cancer Award AI 02425 from the National Institute of Allergy and Infectious Diseases.

▸Requests for reprints should be addressed to Alexander Fefer, M.D.; Department of Medicine, University of Washington; Seattle, WA 98195.


Seattle, Washington; and Edmonton, Alberta,Canada


Ann Intern Med. 1976;84(6):692-695. doi:10.7326/0003-4819-84-6-692
Text Size: A A A

An 18-year-old white Canadian male patient with paroxysmal nocturnal hemoglobinuria and refractory marrow failure received a marrow infusion from his normal identical twin brother without prior ablation of the patient's marrow by drugs or irradiation. After 2 years of follow-up, the patient is well with no evidence of clinical disease or significant hematological abnormality. The results suggest that normal marrow stem cells can have a selective advantage over the abnormal paroxysmal nocturnal hemoglobinuria clone.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)