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Choriocarcinoma with Hyperthyroidism: Probable Identity of the Thyrotropin with Human Chorionic Gonadotropin

WILLIAM T. CAVE Jr., M.D.; and JOHN T. DUNN, M.D.
[+] Article and Author Information

Grant support: by Endocrine Training Grant T- 1-AM-05019 and Research Career Development Award # 1 KO4 AM14846 (JTD), both from the National Institutes of Health.

▸Requests for reprints should be addressed to William T. Cave, Jr., M.D.; Department of Internal Medicine, University of Virginia, Box 252; Charlottesville, VA 22901.


Charlottesville, Virginia


Ann Intern Med. 1976;85(1):60-63. doi:10.7326/0003-4819-85-1-60
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A 15-year-old girl developed severe hyperthyroidism secondary to metastatic choriocarcinoma. Her serum contained high levels of human chorionic gonadotropin (HCG) by radioimmunoassay and had a thyroid-stimulating activity different from that of pituitary thyrotropin (TSH) or of long-acting thyroid stimulator (LATS) in the McKenzie mouse bio-assay. Gradient ultracentrifugation localized this thyroid stimulator to a narrow zone midway between markers of transferrin and ovalbumin. On gel filtration it emerged just before albumin as a single peak coinciding with the peak for HCG. Her HCG was identical to an authentic sample of HCG in position on gel filtration columns and on gel electrophoresis. These results suggest that the thyrotropin of choriocarcinoma is HCG.

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