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Alpha1-Antitrypsin Deficiency and Pancreatic Fibrosis

H. J. FREEMAN, M.D.; W. M. WEINSTEIN, M.D., F.R.C.P.(C); T. K. SHNITKA, M.D., F.R.C.P.(C); P. M. CROCKFORD, M.D., F.A.C.P.(C); and F. A. HERBERT, M.D., F.R.C.P.(C)
[+] Article, Author, and Disclosure Information

Grant support: Dr. Freeman was supported by a Fellowship Grant from the Medical Research Council of Canada.

▸Requests for reprints should be addressed to W. M. Weinstein, M.D., F.R.C.P.(C); 9-112 Clinical Services Building, The University of Alberta; Edmonton. AB, Canada T6G 2G3.

Edmonton, Alberta,Canada

Ann Intern Med. 1976;85(1):73-76. doi:10.7326/0003-4819-85-1-73
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A 39-year-old woman with homozygous ZZ alpha1-antitrypsin deficiency was found to have pancreatic fibrosis in addition to the recognized pulmonary and hepatic abnormalities. Pancreatic exocrine function was normal but endocrine studies showed glucose intolerance. Pancreatic fibrosis may be another manifestation of alpha1-antitrypsin deficiency.





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