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Editorials |

Systemic Contraceptives and Liver Tumors

Ann Intern Med. 1976;85(1):122-123. doi:10.7326/0003-4819-85-1-122
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Since October 1973 when Baum (1) reported seven women with benign liver tumors occurring in association with use of oral contraceptives, more than 100 cases have been reported in various articles, letters to the editor, and editorials. These tumors vary in histologic appearance. Individual cases have been interpreted as representing focal nodular hyperplasia (2, 3) while others have been called liver cell adenomas (4). Support for the concept that these tumors may represent a neoplastic process is provided by recent reports (5, 6) that have identified five women with hepatocellular carcinomas and one with a hepatoblastoma (7) occurring in association


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