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Bleomycin, Adriamycin, Cyclophosphamide, Vincristine, and Prednisone (BACOP) Combination Chemotherapy in the Treatment of Advanced Diffuse Histiocytic Lymphoma

PHILIP S. SCHEIN, M.D., F.A.C.P., M.R.C.P. (U.K.); VINCENT T. DeVITA Jr., M.D., F.A.C.P.; SUSAN HUBBARD, R.N.; BRUCE A. CHABNER, M.D., F.A.C.P.; GEORGE P. CANELLOS, M.D., F.A.C.P.; COSTAN BERARD, M.D.; and ROBERT C. YOUNG, M.D., F.A.C.P.
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▸Requests for reprints should be addressed to Philip S. Schein, M.D.; Division of Medical Oncology, Georgetown University Hospital, Rm. 2230, 3800 Reservoir Rd., N.W.; Washington, D.C. 20007.


Bethesda, Maryland


Ann Intern Med. 1976;85(4):417-422. doi:10.7326/0003-4819-85-4-417
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A new combination chemotherapy program for patients with diffuse histiocytic and mixed histiocytic-lymphocytic lymphoma was designed to prevent tumor recurrence during the recovery period of each treatment cycle. A myelosuppressive phase consisting of adriamycin, cyclophosphamide, and vincristine was followed by the nonmyelosuppressive agents bleomycin and prednisone to suppress regrowth of lymphoma while allowing for a return in bone marrow function. Twelve of 25 patients (48%) with advanced, previously untreated, diffuse histiocytic lymphoma achieved a complete remission as determined by restaging 1 month after discontinuation of treatment. The median duration of complete response after completion of therapy is in excess of 1 year (range, 5 to 30 months), and no patient has relapsed. Based on previous experience, it is anticipated that the majority of these patients will achieve an extended disease-free survival for what had previously been regarded as an invariably fatal disease.

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