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Antibody Response to Influenza Vaccination in Renal Transplant Patients: Correlation with Allograft Function

RUFINO C. PABICO, M.D.; R. GORDON DOUGLAS, M.D., F.A.C.P.; ROBERT F. BETTS, M.D.; BARBARA A. McKENNA, M.S.; and RICHARD B. FREEMAN, M.D., F.A.C.P.
[+] Article and Author Information

This study was supported in part by a contract from the New York State Kidney Disease Institute; and by a contract (Number NO1-AI-22503) from the Infectious Disease Branch, National Institute of Allergy and Infectious Disease, Bethesda, Maryland.

This paper was presented in part at the Primer Simposio Colombiano: Dialysis y Transplante, 30-31 Octobre 1975, Medellin, Colombia; and at the 8th Annual Meeting of the American Society of Nephrology, 25-26 November 1975, Washington, D.C.

▸Requests for reprints should be addressed to Rufino C. Pabico, M.D.; Nephrology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry; Rochester, NY 14642.


Rochester, New York


Ann Intern Med. 1976;85(4):431-436. doi:10.7326/0003-4819-85-4-431
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Thirty renal transplant recipients received 0.5 ml of Influenza Virus Vaccine, Bivalent, USP, intramuscularly. Serum hemagglutination-inhibiting and nasal secretory neutralizing antibodies were measured before and 3 to 4 weeks after vaccination. Creatinine clearance and urinary protein excretion were measured before and weekly for 4 to 8 weeks after vaccination. Ten of 13 patients (77%) with creatinine clearance of ≥ 70 ml/min·1.73m2 (group I) had ≥ a fourfold increase in hemagglutination-inhibiting antibody titers to influenza A or B virus after vaccination, while only six of 17 patients (35%) with creatinine clearance of < 70 ml/min·1.73m2 (group II) had a similar increase (chi-square = 5.129; P < 0.05). Six of 13 patients (46%) in group I had ≥ a fourfold increase in neutralizing antibody titers to influenza A or B virus after vaccination, whereas none in group II had a similar increase (chi-square = 7.135; P < 0.01). There were no adverse effects on the allografts. Only minor side effects were noted in a few patients. Because of its safety and antigenicity, influenza vaccination should be offered to renal transplant recipients particularly during threats of epidemic outbreaks.

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