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Chronic Ulcerative Colitis, Skin Necrosis, and Cryofibrinogenemia

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▸Requests for reprints should be addressed to Gene V. Ball, M.D.; Department of Medicine; 1919 Seventh Avenue South; Birmingham, AL 35294.

Birmingham, Alabama

Ann Intern Med. 1976;85(4):464-466. doi:10.7326/0003-4819-85-4-464
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Necrotizing skin lesions developed in a man with chronic ulcerative colitis. No evidence of intrinsic disease of medium or small-sized vessels was found. A circulating cryofibrinogen was thought to be responsible for in situ thrombosis leading to skin infarctions. Sodium warfarin in a daily dose of 2.5 to 5 mg appears to have thwarted progression of developing lesions and the occurrence of new ones.





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