0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Gonadal Function Abnormalities in Sickle Cell Anemia: Studies in Adult Male Patients

ALI A. ABBASI, M.D., F.R.C.P.(C); ANANDA S. PRASAD, M.D., Ph.D., F.A.C.P.; JESUS ORTEGA, M.D.; EVANGELINE CONGCO, M.D.; and DONALD OBERLEAS, Ph.D.
[+] Article and Author Information

Grant support: by funds from Sickle Cell Disease Branch NHLI, NIH Contract #72-2918; and VA Projects 0025-01 and 5400-01.

▸Requests for reprints should be addressed to Ananda S. Prasad, M.D.; Veterans Administration Hospital; Allen Park, MI 48101.


Allen Park and Detroit, Michigan


Ann Intern Med. 1976;85(5):601-605. doi:10.7326/0003-4819-85-5-601
Text Size: A A A

Thirty-two adult patients with sickle cell anemia were evaluated endocrinologically. Secondary sex characteristics were abnormal in 29, and eunuchoidal skeletal proportions were present in all except one. The age at which different stages of pubic hair growth were attained in these patients was delayed in comparison to normals (P < 0.005). Hormonal assays were carried out in 14 patients. Basal serum testosterone, dihydrotestosterone, and androstenedione values were lower (P < 0.02) in patients than controls. Serum LH and FSH levels before and after stimulation with gonadotropin-releasing hormone were consistent with primary testicular failure. Erythrocyte and hair zinc concentrations were significantly decreased, and there was positive correlation between erythrocyte zinc and serum testosterone (r = 0.61, P < 0.01) in sickle cell anemia. Our study shows that androgen deficiency in this disease is a result of primary rather than secondary hypogonadism. Further studies are required to establish the role of zinc in the pathogenesis of testicular failure in sickle cell anemia.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)