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Interstitial Pneumonia in Angio-Immunoblastic Lymphadenopathy with Dysproteinemia: A Case Report with Special Histopathologic Studies

MICHAEL D. ISEMAN, M.D., F.A.C.P.; MARVIN I. SCHWARZ, M.D.; and RAY E. STANFORD, M.D.
[+] Article and Author Information

Grant support: in part by National Heart and Lung Institute Grant Number 1 RO1 HL 19018-01.

▸Requests for reprints should be addressed to Michael D. Iseman, M.D.; Pulmonary Medicine, Denver General Hospital; Denver, CO 80204.


Ann Intern Med. 1976;85(6):752-755. doi:10.7326/0003-4819-85-6-752
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A patient presented with characteristic historical, physical, and laboratory findings of angio-immunoblastic lymphadenopathy with dysproteinemia. This newly described entity apparently represents a nonneoplastic proliferation of the B-lymphocyte system with immunoblastic transformation of many lymphocytes and excessive production of immunoglobulins. It is associated with fever, sweats, weight loss, skin rash, lymphadenopathy, splenomegaly, hepatomegaly, and characteristic histologic features of the involved lymph nodes. Noteworthy in the patient reported here are the extent and course of radiographically and clinically evident pulmonary involvement and the biopsy documentation of an interstitial pneumonia marked by histopathologic changes closely resembling those found in the lymph nodes, with immunohistologic demonstration of immunoglobulins in the alveolar walls.

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