0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Granulocyte Adherence Changes Induced by Hemodialysis, Endotoxin, Epinephrine, and Glucocorticoids

ROB ROY MacGREGOR, M.D.
[+] Article and Author Information

Grant support: in part by Grant AA 00332 from the National Institute for Alcohol Abuse and Alcoholism.

▸Requests for reprints should be addressed to Rob Roy MacGregor, M.D.; Infectious Diseases Section, 552 Johnson Pavilion/G2, University of Pennsylvania School of Medicine; Philadelphia, PA 19174.


Philadelphia, Pennsylvania


Ann Intern Med. 1977;86(1):35-39. doi:10.7326/0003-4819-86-1-35
Text Size: A A A

Granulocyte adherence was studied in several situations of altered granulocyte kinetics. During the transient granulocytopenia of hemodialysis, adherence increased to 481.7% of baseline by 15 min and was normal by 60 min. One hour after endotoxin administration, adherence was 160.5% of control as granulocyte counts fell to 21.4%; conversely, the 24-h postdose granulocytosis was associated with a 43.0% decrease in adherence. Epinephrine produced a 25.8% decrease in adherence, with demargination granulocytosis 146.1% of control period. Alternate-day prednisone administration inhibited adherence by 38.9% on the "on" day, concomitant with prolonged granulocyte intravascular half-life, but adherence returned to normal on the "off" day when intravascular half-life is normal. In each situation, a plasma factor not present in serum was responsible for the modified adherence; if these factors produce the same adherence changes in vivo, they may be responsible for the alterations noted in granulocyte kinetics.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)