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Granulocyte Adherence Changes Induced by Hemodialysis, Endotoxin, Epinephrine, and Glucocorticoids

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Grant support: in part by Grant AA 00332 from the National Institute for Alcohol Abuse and Alcoholism.

▸Requests for reprints should be addressed to Rob Roy MacGregor, M.D.; Infectious Diseases Section, 552 Johnson Pavilion/G2, University of Pennsylvania School of Medicine; Philadelphia, PA 19174.

Philadelphia, Pennsylvania

Ann Intern Med. 1977;86(1):35-39. doi:10.7326/0003-4819-86-1-35
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Granulocyte adherence was studied in several situations of altered granulocyte kinetics. During the transient granulocytopenia of hemodialysis, adherence increased to 481.7% of baseline by 15 min and was normal by 60 min. One hour after endotoxin administration, adherence was 160.5% of control as granulocyte counts fell to 21.4%; conversely, the 24-h postdose granulocytosis was associated with a 43.0% decrease in adherence. Epinephrine produced a 25.8% decrease in adherence, with demargination granulocytosis 146.1% of control period. Alternate-day prednisone administration inhibited adherence by 38.9% on the "on" day, concomitant with prolonged granulocyte intravascular half-life, but adherence returned to normal on the "off" day when intravascular half-life is normal. In each situation, a plasma factor not present in serum was responsible for the modified adherence; if these factors produce the same adherence changes in vivo, they may be responsible for the alterations noted in granulocyte kinetics.





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