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Plasma Glucose Levels: Long-Term Effect of Diet in the Chicago Coronary Prevention Evaluation Program

EDUARDO FARINARO, M.D.; JEREMIAH STAMLER, M.D.; MELISSA UPTON, A.B.; LOUISE MOJONNIER, Ph.D.; YOLANDA HALL, M.S.; DOROTHY MOSS, M.S.; and DAVID M. BERKSON, M.D.
[+] Article and Author Information

Grant support: by grants from the American Heart Association; the Chicago Heart Association; the Best Foods Institute of Nutrition; the National Dairy Council; the National Heart and Lung Institute of the National Institutes of Health (HE 04197 and HE 09426); and the Wesson Fund for Medical Research.

▸Requests for reprints should be addressed to Jeremiah Stamler, M.D.; Department of Community Health and Preventive Medicine, Northwestern University Medical School, 303 E. Chicago Ave.; Chicago, IL 60611.


Chicago, Illinois


Ann Intern Med. 1977;86(2):147-154. doi:10.7326/0003-4819-86-2-147
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In 150 middle-aged men prone to coronary disease, long-term data based on the Chicago Coronary Prevention Evaluation Program's diet showed that there was a favorable effect on fasting glycemia level and glucose tolerance. This diet for reducing obesity and hypercholesterolemia was low in cholesterol and saturated fat and moderate in polyunsaturated and total fat, with replacement of some fat by carbohydrate. At 2 years, decreased weight and serum cholesterol values of normoglycemic men were accompanied by a modest but significant fall in fasting and postload glycemia; at 4 years, fasting glycemia levels remained slightly below baseline. For men with suspect fasting hyperglycemia at baseline, sustained fall in weight and serum cholesterol value was associated with sizeable long-term reductions in fasting glycemia and improvement of glucose tolerance. Decrease in plasma glucose was significantly related to decrease in weight. No evidence of impairment of glucose tolerance with years-long consumption of this diet was recorded.

Topics

diet ; plasma glucose

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