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Original Research |

Intravascular Hemolysis, Thrombocytopenia, Leukopenia, and Circulating Immune Complexes after Jejunal-Ileal Bypass Surgery

J. L. MOAKE, M.D.; W. V. KAGELER, M.D.; P. L. CIMO, M.D.; R. W. BLAKELY, M.D.; R. D. ROSSEN, M.D.; and W. HAESSE, M.D.
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▸Requests for reprints should be addressed to J. L. Moake, M.D.; University of Texas Medical School; 6400 West Cullen Street; Houston, TX 77030.

Houston, Texas

Ann Intern Med. 1977;86(5):576-578. doi:10.7326/0003-4819-86-5-576
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Two years after jejunal-ileal bypass surgery for obesity, a 25-year-old man developed intravascular hemolysis, thrombocytopenia, and neutropenia. The patient's erythrocytes were coated with complement components (C4/C3) and his serum induced complement-dependent immune lysis of chromium-51-labeled platelets. Serum [125I]-C1q binding activity (a measure of the presence of immune complexes) was increased, and serum C4 and C3 hemolytic titers were depressed. Immune complex-mediated complement activation apparently accounted for the blood cell destruction in this patient.





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