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Furosemide-Induced Reduction in Ionized Calcium in Hypoparathyroid Patients

PATRICIA A. GABOW, M.D.; THOMAS J. HANSON, M.D.; MORDECAI M. POPOVTZER, M.D.; and ROBERT W. SCHRIER, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Patricia A. Gabow, M.D.; Department of Medicine, Denver General Hospital, 8th and Cherokee; Denver, CO 80204.


Denver, Colorado


Ann Intern Med. 1977;86(5):579-581. doi:10.7326/0003-4819-86-5-579
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Six hypoparathyroid patients were treated with oral furosemide for 4 days. All six had a significant decrease in serum ionized calcium level from the control period (4.05 ± 0.31 mg/dl) to the furosemide period (3.46 ± 0.26 mg/dl, P < 0.005). In five patients, the decrease in serum ionized calcium concentration occurred in association with an increase in urinary calcium excretion. Although serum immunoreactive parathyroid hormone level increased in five patients, it was insufficient to return serum ionized calcium to control levels. Changes in serum phosphorus, magnesium, or pH could not account for the observed decrease in serum ionized calcium concentration. It is necessary to monitor serum ionized calcium level in hypoparathyroid patients during furosemide therapy.

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