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Liver Biopsy in Hemophilia A

HENRY R. LESESNE, M.D.; JOHN E. MORGAN, M.D.; PHILIP M. BLATT, M.D.; WILLIAM P. WEBSTER, D.D.S.; and HAROLD R. ROBERTS, M.D.
[+] Article and Author Information

Portions of the results of this investigation were presented at a workshop, "Unsolved Therapeutic Problems in Hemophilia," sponsored by the National Institutes of Health, 1 and 2 March 1976, Bethesda, Maryland (35).

▸Requests for reprints should be addressed to Henry R. Lesesne, M.D.; Division of Gastroenterology, University of North Carolina School of Medicine; Chapel Hill, NC 27514.


Chapel Hill, North Carolina


Ann Intern Med. 1977;86(6):703-707. doi:10.7326/0003-4819-86-6-703
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Hepatitis is a significant complication of the treatment of hemophilia A with factor VIII concentrates. Chronic liver disease in these patients is infrequently documented in the literature. The results of percutaneous liver biopsy, under the coverage of glycine-precipitated factor VIII, in six patients with hemophilia A who had the persistence of abnormal liver-function tests for at least 6 months, are described. Three patients had chronic active hepatitis, and three had chronic persistent hepatitis. No complications were encountered as a result of the biopsy procedure. These results suggest that percutaneous liver biopsy should be considered in patients with hemophilia A with continuously abnormal liver-function tests to establish a histologic diagnosis and to guide further therapy.

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