0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Alpha1-Antitrypsin Deficiency with Severe Panniculitis: Report of Two Cases

HERBERT M. RUBINSTEIN, M.D., F.A.C.P.; ADRIAN M. JAFFER, M.D.; JAMES C. KUDRNA, M.D.; Y. LERTRATANAKUL, M.D.; A. J. CHANDRASEKHAR, M.D.; D. SLATER, M.D.; and FRANK R. SCHMID, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: in part by U.S. Public Health Service Training Grant AM 05069 and an Arthritis Foundation Clinical Research Grant.

▸Requests for reprints should be addressed to Herbert M. Rubinstein, M.D.; Section of Rheumatology, Loyola University Stritch School of Medicine, 2160 South First Ave.; Maywood, IL 60153.


Maywood and Chicago, Illinois


Ann Intern Med. 1977;86(6):742-744. doi:10.7326/0003-4819-86-6-742
Text Size: A A A

Two patients with profound decrease of alpha1-antitrypsin (PiZZ) presented with severe panniculitis (Weber-Christian disease); one had systemic panniculitis including pancreatitis. Another possible case is quoted from the literature. Although milder forms of panniculitis can have normal Pi phenotypes and alpha1-antitrypsin levels, the marked reduction of antiproteolytic activity found in PiZZ homozygotes may predispose to or aggravate the lesions of Weber-Christian disease.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)