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Chronic Hepatitis in Hemophilia

LEONARD B. SEEFF, M.D.; and JAY HOOFNAGLE, M.D.
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Departments of Medicine, Veterans Administration Hospital and Georgetown University School of Medicine; Washington, D.C.


Ann Intern Med. 1977;86(6):818-820. doi:10.7326/0003-4819-86-6-818
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Persons with hemophilia are at unusually high risk of developing acute viral hepatitis as a result of their need for repeated treatment with blood products. Although less than one fourth of adult hemophiliac patients have a history of acute hepatitis, at least three fourths of them can be shown by serologic tests for the hepatitis B surface antigen (HBsAg) and antibody (antiHBs) to have been exposed to type B hepatitis (1). Some recent evidence has suggested that chronic hepatitis might also be common in this population (2), a consequence of treatment with blood products that might have been predicted. Prospective

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