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Cryptococcosis and Cushing's Syndrome

Ann Intern Med. 1977;87(1):65-66. doi:10.7326/0003-4819-87-1-65
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Although cryptococcosis complicating steroid therapy is well described, cryptococcosis has not, to our knowledge, been reported in the English language literature since 1950 in the presence of Cushing's syndrome secondary to endogenous steroid excess. Accordingly, a case is described of fulminant cryptococcal pneumonia with dissemination and development of meningitis complicating Cushing's syndrome, probably secondary to an ectopic ACTH-producing hepatic adenocarcinoma.

A 59-year-old white man presented 1 month before his present admission, with Cushing's syndrome. The morning serum cortisol level was 64 µg/dl, and the evening serum cortisol level was 80 µg/dl. The 24-h urine cortisol was 7150 µg (normal range,


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