0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Reviews |

The Role of Autoimmunity in Hypoendocrine and Hyperendocrine Function: With Special Emphasis on Autoimmune Thyroid Disease

ROBERT VOLPÉ, M.D., F.A.C.P., F.R.C.P.(C)
[+] Article and Author Information

Grant support: work cited from the author's laboratory has been supported by grants from the Medical Research Council of Canada (MT859).

This paper was presented as a "State of the Art" address at the 58th annual meeting of The Endocrine Society, 23-25 June 1976, San Francisco, California.

▸Requests for reprints should be addressed to Robert Volpé, M.D.; Room 112D, Jones Bldg., The Wellesley Hospital, 160 Wellesley St. E.; Toronto, ON M4Y 1J3, Canada.


Toronto, Canada


Ann Intern Med. 1977;87(1):86-99. doi:10.7326/0003-4819-87-1-86
Text Size: A A A

There is considerable evidence to suggest that the organspecific autoimmune endocrinopathies are primary disorders of the lymphoid system. Although proof is not complete, the basic genetic defect in each condition may be one of immune surveillance, that is, a defect in suppressor "T" lymphocytes. Combinations of two or more of these conditions may be due to the concurrence of two or more specific defects in immune control, as well as the random appearance of the appropriate self-directed "forbidden" clones of lymphocytes. In this concept, there is no need for antigenic alteration (only antigenic availability) to initiate these disorders. Both cell-mediated and humoral immunity seem essential, with roles for immune complexes and "killer" cells as well. Antireceptor antibodies are of particular interest in Graves' disease, where they are stimulatory: other antireceptor antibodies have been found that are blocking antibodies, and others may merely bind without either stimulating or blocking.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)