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Fatty Liver and Pleural Effusion with Ibuprofen Therapy

JAIME F. BRAVO, M.D.; MICHAEL P. JACOBSON, M.D.; and BENNY F. MERTENS, M.D.
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Department of Medicine
University of Colorado Medical Center
Denver, CO 80218


Ann Intern Med. 1977;87(2):200-201. doi:10.7326/0003-4819-87-2-200
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New nonsteroidal anti-inflammatory agents have been notably free from serious side effects. We report here a case of fatal fatty metamorphosis of the liver and pleural effusions in an atopic individual with mixed connective tissue disease treated with ibuprofen (Motrin®) and ampicillin.

A 48-year-old woman was first seen on 19 June 1975. She complained of symmetrical polyarthritis for 7 years as well as dry eyes and mouth, Raynaud's phenomenon, dysphagia, and weight loss for the last year. Only aspirin, 2.6 g daily, had been taken for the 3 months before her initial evaluation. She was allergic to streptomycin and para-aminosalicylic

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