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Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination Chemotherapy in Disseminated Testicular Cancer

LAWRENCE H. EINHORN, M.D., F.A.C.P.; and JOHN DONOHUE, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Lawrence H. Einhorn, M.D., F.A.C.P.; Indiana University School of Medicine; 110 West Michigan Street; Indianapolis, IN 46202.


Indianapolis, Indiana


Ann Intern Med. 1977;87(3):293-298. doi:10.7326/0003-4819-87-3-293
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Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered inevaluable due to early death. This chemotherapy regimen produced 74% complete and 26% partial remissions. Furthermore, five patients with partial remission became disease-free after surgical removal of residual disease, producing an overall 85% disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable, although there were two drug-related deaths during this period. Thirty-eight of these patients remain alive and 32 remain alive and disease-free at 6+ to 30+ months. We believe this regimen represents a major advance in the management of patients with disseminated testicular cancer.

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