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Chronic Liver Disease and Acetaminophen

[+] Article, Author, and Disclosure Information

▸ Requests for reprints should be addressed to Keith G. Tolman, M.D., F.A.C.P.; Division of Gastroenterology, Department of Internal Medicine, University of Utah Medical Center; Salt Lake City, UT 84132.

Salt Lake City, Utah

Ann Intern Med. 1977;87(3):302-304. doi:10.7326/0003-4819-87-3-302
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A 59-year-old female patient with arthritis developed liver function abnormalities while taking therapeutic doses of acetaminophen. Liver biopsy showed evidence of acute and chronic liver damage. Rechallenge with acetaminophen induced abnormal liver functions almost immediately. The patient has been followed for 2 years since that challenge and remains asymptomatic. Biochemical tests of liver function have returned to normal.





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