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Phenformin and Hyperamylasemia in Lactic Acidosis

LYDIA A. CONLAY, M.D.; and JOSEPH E. LOEWENSTEIN, M.D., F.A.C.P.
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▸Requests for reprints should be addressed to Joseph E. Loewenstein, M.D., F.A.C.P.; Chief, Section of Endocrinology, Louisiana State University Medical Center; P.O. Box 33932; Shreveport, LA 71130.


Ann Intern Med. 1977;87(3):312-313. doi:10.7326/0003-4819-87-3-312
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All cases of lactic acidosis occurring during a 23-month period in a metropolitan teaching hospital were reviewed to ascertain the frequency of hyperamylasemia. Serum amylase activity had been measured in 12 of 26 patients and was elevated in eight (67%). Hyperamylasemia was not significantly more frequent in patients with phenformin-associated lactic acidosis than in patients with lactic acidosis who had not received phenformin. Serum amylase activity did not correlate with the severity of acidosis (arterial pH) or with renal function (serum creatinine).

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Phenformin and hyperamylasemia in lactic acidosis. Ann Intern Med 1977;87(3):312-3.
[Lactic acidosis, hyperamylasemia, and phenformin]. Minerva Med 1992;83(12):777-83.
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