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Histamine H-2 Receptor Antagonists

Ann Intern Med. 1977;87(3):373-375. doi:10.7326/0003-4819-87-3-373
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The actions of histamine are mediated by two types of receptors that are present on a number of morphologically distinct cell types (1). Those mediating mepyramine-sensitive histamine responses are defined as H-1 receptors. H-2 receptors, which mediate histamine effects on gastric acid secretion, cardiac pacemaker, and a growing list of other actions (1), are blocked by a new class of compounds first synthesized by Black and colleagues (2). They have also described specific agonists for H-1 (2-methyl histamine) and H-2 (4-methyl histamine) receptors. These and newer H-1 and H-2 specific agonists and antagonists have been used in a large number


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