The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

H2-Histamine Receptor Blocking Agents in the Zollinger-Ellison Syndrome: Experience in Seven Cases and Implications for Long-Term Therapy

D. M. MCCARTHY, M.D., F.R.C.P.I., F.A.C.P.; E. J. OLINGER, M.D.; R. J. MAY, M.D.; B. W. LONG, M.D.; and J. D. GARDNER, M.D.
[+] Article, Author, and Disclosure Information

▸Requests for reprints should be addressed to Denis M. McCarthy, M.D.; National Institute of Arthritis, Metabolism and Digestive Diseases, Bldg. 10, Rm. 9D-17, National Institutes of Health; Bethesda, MD 20014.

Bethesda, Maryland

Ann Intern Med. 1977;87(6):668-675. doi:10.7326/0003-4819-87-6-668
Text Size: A A A

H2-Histamine receptor blocking agents metiamide and cimetidine were assessed in seven patients with Zollinger-Ellison syndrome (serum gastrin > 300 µg/ml, basal acid output > 15 meq/h, ratio of basal acid output to maximal acid output > 0.5). Intravenous or oral administration of the drugs lowered acid secretion by at least 70% in all cases. Subsequent treatment of six patients for 3 to 15 months (oral therapy) and one patient for 1 month (intravenous therapy) showed that the drugs abolished symptoms in all seven, abolished diarrhea in five, allowed ulcer healing in six, and were well tolerated without adverse effects in seven. No patient failed to respond to the drug, although one died from tumor progression and two required total gastrectomy for complex reasons. The results indicate that patients with Zollinger-Ellison syndrome can be managed medically and, in light of current mortality trends, gain little from the extra risks attending total gastrectomy.





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.