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Tamoxifen (Antiestrogen) Therapy in Advanced Breast Cancer

DAVID T. KIANG, M.D., Ph.D.; and BJ. KENNEDY, M.D.
[+] Article and Author Information

Grant support: by research grants CB-64000, CA-19527, and CA-08832 from the National Cancer Institute, U.S. Public Health Service: the Minnesota Medical Foundation; and the Masonic Memorial Hospital Fund, Inc.

This paper was presented at the 58th Annual Session of the American College of Physicians, Dallas, Texas, April 1977.

▸Requests for reprints should be addressed to David T. Kiang, M.D.; Box 168, University Hospitals; Minneapolis, MN 55455.


Minneapolis, Minnesota


Ann Intern Med. 1977;87(6):687-690. doi:10.7326/0003-4819-87-6-687
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Fifty-nine postmenopausal women with advanced breast cancer were treated with tamoxifen (antiestrogen), 20 mg orally twice a day for at least 2 months. They had been previously treated with other types of hormonal therapy or intensive chemotherapies, or both. Nineteen of the 59 patients (32%) had either a complete response (seven patients) or partial response (12 patients). The median duration of response was 9 + months. Tumors containing estrogen receptors and those that responded to previous hormonal manipulation tended to respond to tamoxifen (60% and 69%, respectively). Patients with receptor-negative tumor or with a history of failure of previous hormonal treatments did not respond to tamoxifen therapy. Tamoxifen is effective against advanced breast cancer. Side effects of the treatment were mild.

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