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Scleroderma, Sjögren-like Syndrome, and Chronic Graft-Versus-Host Disease

THOMAS J. LAWLEY, M.D.; GARY L. PECK, M.D.; HARALAMPOS M. MOUTSOPOULOS, M.D.; ALOIS A. GRATWOHL, M.D.; and ALBERT B. DEISSEROTH, M.D., Ph.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Thomas J. Lawley, M.D.; Dermatology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. 12-N-238; Bethesda, MD 20014.


Bethesda, Maryland


Ann Intern Med. 1977;87(6):707-709. doi:10.7326/0003-4819-87-6-707
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A patient with acute myelogenous leukemia treated with an allogeneic bone marrow transplant developed acute graft-versus-host disease manifested by severe diarrhea, hepatitis, and a cutaneous eruption. As the graft-versus-host disease progressed to the chronic phase, the patient developed marked cutaneous sclerosis and symptoms of xerophthalmia and xerostomia. Biopsy of his indurated skin showed features of both graft-versus-host disease and scleroderma. Results of Schirmer's tests, corneal fluorescent studies, parotid flow-rate testing, and a lip biopsy were consistent with Sjögren's syndrome. Possibly, activated lymphocytes may have a role in the pathogenesis of graft-versus-host disease, scleroderma, and Sjögren's syndrome.

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