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Platelet Hyperaggregability and Thrombosis in Patients with Thrombocythemia

KENNETH KUN-YU WU, M.D., F.A.C.P.
[+] Article and Author Information

Grant support: by a grant from the American Heart Association, with funds contributed in part by the Chicago Heart Association.

▸Requests for reprints should be addressed to Kenneth K. Wu, M.D.; Coagulation-Thrombosis Unit, Section of Hematology, Rush-Presbyterian-St. Luke's Medical Center, 1753 West Congress Parkway; Chicago, IL 60612.


Chicago, Illinois


©1978 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1978;88(1):7-11. doi:10.7326/0003-4819-88-1-7
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The relation between platelet hyperaggregability and thrombosis was assessed in 28 patients with thrombocythemia due to myeloproliferative diseases and 11 with reactive thrombocytosis. None of the patients with reactive thrombocytosis had thrombotic or hemorrhagic complications, but thrombosis was noted in seven patients and bleeding in two patients with thrombocythemia. Nineteen were asymptomatic. In patients with thrombosis, bleeding time, platelet glass retention, and clot retraction were normal, but evidence of platelet hyperaggregability was present in all but one. Serial studies on six patients revealed a close association between platelet hyperaggregability and ischemic attacks. Neither patient with bleeding complications had evidence of platelet hyperaggregability, although poor platelet function was found in one. Platelet function in asymptomatic patients can be classified as hyperactive, hypoactive, or normal.

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