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Myocardial Infarction: Unit Care or Home Care?

OSLER L. PETERSON, M.D.
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Leonard Davis Institute of Health Economics, University of Pennsylvania; Philadelphia, Pennsylvania


Ann Intern Med. 1978;88(2):259-261. doi:10.7326/0003-4819-88-2-259
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About 1940, the late Maurice B. Strauss, then a junior faculty member of Harvard's Thorndike Laboratory, presented a graph showing the natural history of a new drug's use. His graph showed that, in 1940, a newly marketed drug was at first accepted slowly by clinicians. A period of accelerated growth soon resulting in wide use followed, and then excessive use. This excess, together with appearances of drug reactions, caused the initial enthusiasm to fade, bringing about a sharp decline. This was followed in turn by reassessment of the drug, which, Strauss felt, resulted in more judicious use.

Since Strauss formulated

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