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Editorials |

Smoking and Theophylline Dose Schedules

R.I. OGILVIE, M.D.
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Division of Clinical Pharmacology, Montreal General Hospital, Montreal, Canada


Ann Intern Med. 1978;88(2):263-264. doi:10.7326/0003-4819-88-2-263_2
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This excerpt has been provided in the absence of an abstract.

Theophylline is eliminated almost entirely by biotransformation in the liver. It is not surprising that changes in liver function alter the disposition of theophylline: Patients with hepatic cirrhosis have a markedly reduced capacity to eliminate it (1). More subtle changes in liver function associated with alterations in dietary protein and carbohydrate (2) and smoking (3-5) have also been observed.

The enzymes responsible for biotransformation of theophylline in the liver are not known but probably include cytochrome P-448, which can be induced by substances contained in cigarette smoke such as 3,4-benzypyrene and related polycyclic hydrocarbons. This is a different enzyme system

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