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Sex, Cadavers, and Histocompatibility Matching in Renal Transplantation

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Institute for Cancer Research, Fox Chase Cancer Center; Philadelphia, Pennsylvania

Ann Intern Med. 1978;88(2):264-265. doi:10.7326/0003-4819-88-2-264
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At the first International Transplantation Conference held in New York in 1954, Peter Gorer presented evidence of an antibody response to skin allografts in mice. He thought that these antibodies were directed against H-2 antigens and stated that "if homografts are to be used in clinical practice . . . it will be desirable to type people in order to prolong the life of the graft" (1). The identification of HLA antigens in humans made Gorer's prediction possible, and the principles of allografting, learned from experiments with inbred strains of mice, were applied to humans. Humans, however, are an outbred


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